There is a theoretical relationship between wd40 the occurrence of lactic acidosis wd40 and the use of drugs containing propylene glycol at high doses for prolonged periods. We conducted a retrospective study from a series of six pediatric patients who received pentobarbital, phenytoin wd40 or phenobarbital for at least 12 hours. No cases of lactic wd40 acidosis have been reported in six patients.
Objectives: To evaluate the presence of lactic wd40 acidosis in patients treated with phenytoin (8.29 mg / mL PG), pentobarbital (8.31 mg / ml PG) and phenobarbital (6.56 mg / mL PG) to pediatric intensive care.
Methodology: descriptive study, retrospective case presentations. The study is taking place at the CHU Sainte-Justine, a mother-child facility with 500 beds. From the pharmacological computerized record, we identified patients receiving phenytoin, phenobarbital and pentobarbital for a period of at least 12 hours. Were included all patients from January 1 to December 31, 2011. For each patient, we calculated the dose in mg / kg / day received PG calculated osmolar gap and documented blood pH.
Results: Six patients received combinations of these three medications for episodes 4-15 days of treatment for a total cumulative dose of PG 964-3184 mg / kg. All patients received pentobarbital and phenytoin; two patients received phenobarbital. Patients received No patient had lactic acidosis with minimum and maximum wd40 values of pH [7.37-7.44] and average values of osmolar gap of 7.4, respectively; wd40 9.1; 11.3; 12.1; 18.3 and 18.4.
Conclusion: The use of drugs with PG includes theoretical risk of lactic wd40 acidosis. No cases were reported in six patients treated with three drugs containing PG. It does not appear useful to monitoring the serum PG. However, a study in a larger number of higher cumulative doses to patients could be considered.
On the same theme This entry was posted in Good use of drugs, Case, side effects, morbidity, Pharmaceutical Care, RUPP and marked with lactic acidosis, pentobarbital, phenobarbital, phenytoin, propylene glycol, December 11, 2014 by Cynthia Tanguay. Navigation How to define an Author? Management of rare inherited metabolic disorders at the CHU Sainte-Justine
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