Wednesday, February 12, 2014

Pyridine rings Moreover, the researcher also prepared compounds containing pyridine rings. The stru

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The researcher Lidia Garcia has contributed to the development isotope of a chemical reaction that allows the construction of the basic structure of numerous drugs and natural products in a single reaction step, unlike most existing methods that require the pharmaceutical isotope industry several synthetic steps.
The development of new chemical isotope processes is an issue of particular importance in the pharmaceutical industry. Specifically, the cycloaddition reaction [2 +2 +2] promoted by transition metals is a highly efficient synthetic tool. Chemistry researcher at the University of Girona (Girona) Lidia Garcia has developed various aspects of this reaction, which allows obtaining compound isotope benzene and pyridine, ie, basic structures of many drugs available today, in one reaction step. It is a process that chemists call "atom economy", this means that all the atoms of the reactants become part of the product and minimizes waste generation.
The researcher has studied its application in the preparation of highly efficient products with biological interest. On one hand, Lidia Garcia synthesized unnatural amino acids derived from phenylalanine enantiomerically pure. The methodology has allowed the introduction of fluorescent isotope markers in the new amino potentially interesting in the field of medicinal chemistry. The fluorescent markers are a valuable alternative to the classic radioactive isotopes.
Pyridine rings Moreover, the researcher also prepared compounds containing pyridine rings. The structure of pyridine is different isotope drugs and natural compounds such as niacin, vitamin B3, which is essential in energy metabolism of the cells, isotope or vitamin B6 consists of a set of three compounds (pyridoxine, pyridoxal and pyridoxamine ), all containing the basic structure of pyridine.
The result of a collaboration with the group of doctors and Mayoral Caminade CNRS Toulouse, Lidia Garcia has developed a new type of catalyst, a substance that increases the reaction rate, which can work effectively isotope in mild reaction conditions . This new catalyst showed high activity and selectivity unprecedented. In addition, the new catalytic system has the peculiarity of allowing its recovery and reuse multiple isotope times, which matches isotope one of the basic principles of what is called "green chemistry."
The researcher Lidia Garcia (San Celoni, 1984) graduated in Chemistry isotope from the University of Girona in 2007. Then he joined the research group Transition Metals in Organic Synthesis of Girona where he developed his thesis "cycloaddition reactions [2 +2 +2] catalyzed by Rh (I)" under the direction of Drs Anna and Anna Quintana Roglans isotope Plan. Since then, he has gained experience in the fields of organic and organometallic synthesis and catalysis.
The young chemistry has published five articles isotope in prestigious international journals and has participated in several national and international conferences as a speaker. In addition, in recognition of the quality of their research, in 2010 he received the St. George Award of the Catalan Society of Chemistry for the best research work in chemistry.


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